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Friday, May 3, 2013

Gray hair and vitiligo reversed at the root

May 3, 2013 ? Hair dye manufacturers are on notice: The cure for gray hair is coming. That's right, the need to cover up one of the classic signs of aging with chemical pigments will be a thing of the past thanks to a team of European researchers. In a new research report published online in The FASEB Journal people who are going gray develop massive oxidative stress via accumulation of hydrogen peroxide in the hair follicle, which causes our hair to bleach itself from the inside out, and most importantly, the report shows that this massive accumulation of hydrogen peroxide can be remedied with a proprietary treatment developed by the researchers described as a topical, UVB-activated compound called PC-KUS (a modified pseudocatalase). What's more, the study also shows that the same treatment works for the skin condition, vitiligo.

"To date, it is beyond any doubt that the sudden loss of the inherited skin and localized hair color can affect those individuals in many fundamental ways," said Karin U. Schallreuter, M.D., study author from the Institute for Pigmentary Disorders in association with E.M. Arndt University of Greifswald, Germany and the Centre for Skin Sciences, School of Life Sciences at the University of Bradford, United Kingdom. "The improvement of quality of life after total and even partial successful repigmentation has been documented."

To achieve this breakthrough, Schallreuter and colleagues analyzed an international group of 2,411 patients with vitiligo. Of that group, 57 or 2.4 percent were diagnosed with strictly segmental vitiligo (SSV), and 76 or 3.2 percent were diagnosed with mixed vitiligo, which is SSV plus non-segmental vitiligo (NSV). They found that for the first time, patients who have SSV within a certain nerval distribution involving skin and eyelashes show the same oxidative stress as observed in the much more frequent general NSV, which is associated with decreased antioxidant capacities including catalase, thioredoxin reductase, and the repair mechanisms methionine sulfoxide reductases. These findings are based on basic science and clinical observations, which led to successful patient outcomes regarding repigmentation of skin and eyelashes.

"For generations, numerous remedies have been concocted to hide gray hair," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "but now, for the first time, an actual treatment that gets to the root of the problem has been developed. While this is exciting news, what's even more exciting is that this also works for vitiligo. This condition, while technically cosmetic, can have serious socio-emotional effects of people. Developing an effective treatment for this condition has the potential to radically improve many people's lives."

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The above story is reprinted from materials provided by Federation of American Societies for Experimental Biology, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

K. U. Schallreuter, M. A. E. L. Salem, S. Holtz, A. Panske. Basic evidence for epidermal H2O2/ONOO--mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS. The FASEB Journal, 2013; DOI: 10.1096/fj.12-226779

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/sKpMQ44myiE/130503132958.htm

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Thursday, May 2, 2013

Deadman's March

RolePlayGateway is proudly powered by obscene amounts of caffeine, duct tape, and support from people like you. It operates under a "don't like it, suggest an improvement" platform, and we gladly take suggestions for improvements or changes.

The custom-built "roleplay" system was designed and implemented by Eric Martindale as of July 2009. All attempts to replicate or otherwise emulate this system and its method of organizing roleplay are strictly prohibited without his express written and contractual permission; violators will be prosecuted to the fullest extent of the law.

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Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/gcOcz3BXcVA/viewtopic.php

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Olympus PEN E-P5 mirrorless camera leak suggests 16-megapixel, WiFi flagship

Olympus is about to add another branch to your camera-buying decision tree judging by new images and specs that leaked out showing a new PEN E-P5 model. The classically shaped Micro Four Thirds flagship was shown in leaked photos along with specs pointing to a 16-megapixel sensor, WiFi, a 1.04 million dot tilt screen, 5-axis stabilization and 5fps burst shooting -- if accurate. While an earlier teaser from Olympus suggests it'll launch around May 11th in China, none of the tea-leaf readers have divined a price yet -- though a look at the company's last mirrorless flagship, the PEN E-P3, might give a clue. You can catch several more photos after the break.

Filed under: Cameras

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Via: 43Rumors

Source: Mobile01, 43Rumors

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Tg5zybYvIH8/

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Locked Out of Your Facebook Account? Trusted Contacts Will Save You

Starting today, Facebook is rolling out a new Trusted Contacts feature under your account security settings. Here, you can pick three to five folks who will have the power to help you when you lock yourself out of your account like a dummy.

Wednesday, May 1, 2013

Digital Multiplex: Jack Reacher, Mama and More

Two sisters disappeared the day their mother was murdered, and after years of searching, their uncle Lucas (Nikolaj Coster-Waldau) and his girlfriend Annabel (Jessica Chastain) find the girls and bring them home. But soon, the sisters seem to be communicating with a spectral entity.

Available to own now on: Amazon, iTunes, Vudu

Source: http://www.rottentomatoes.com/m/1927332/news/1927332/

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Markers related to ovarian cancer survival and recurrence identified

Apr. 29, 2013 ? Researchers at the University of Illinois have identified biomarkers that can be used to determine ovarian cancer survival and recurrence, and have shown how these biomarkers interact with each other to affect these outcomes.

Their findings appear in the journal PLOS ONE.

Researchers try to find molecules called biomarkers that help determine a person's likelihood of getting a disease or, if they have already been diagnosed, how far the disease has advanced. Genes, transcription factors and microRNAs are often used as biomarkers because these molecules can be heralds of disease or portents of susceptibility.

Genes are segments of DNA that code for proteins or other molecules that perform the functions of the cell. Transcription factors regulate these genes by binding to specific DNA sequences, preventing or inducing the genes to be "expressed" at higher or lower levels. MicroRNAs, as their name suggests, are small RNA molecules that regulate an intermediate stage of gene expression. Transcription factors and microRNAs also can regulate each other.

The relationships among transcription factors, microRNAs and target genes can be visualized as interconnected networks. These intricate webs are often used to determine how diseases such as cancer proceed. Analyzing how these networks function in cancer can offer insight into how tumor cells proliferate and differentiate, undergo (or resist) programmed cell death, and how likely they are to become invasive.

According to the American Cancer Society, an estimated 22,240 women will be diagnosed with ovarian cancer in 2013, and 14,230 will die of the disease; this makes ovarian cancer the fifth most common cause of cancer death in women.

The high prevalence of ovarian cancer and ovarian cancer deaths in the U.S. prompted U. of I. animal sciences professor Sandra Rodriguez-Zas and doctoral researcher Kristin Delfino to search for biomarkers associated with ovarian cancer survival and recurrence.

"We knew that there are specific biomarkers that have been associated with ovarian cancer, but we were looking at whether we could more accurately predict survival or age at cancer recurrence considering hundreds of interacting biomarkers simultaneously," Rodriguez-Zas said.

The team used data from the Cancer Genome Atlas, which contains information about ovarian cancer patients' age, survival, cancer recurrence, treatment, tumor stage, tumor grade and genomic expression. The researchers then performed statistical tests to tie these factors to patients' survival time, measured in months from diagnosis to death, and their recurrence time, measured in months from diagnosis to recurrence.

"The networks change for people who have different rates of survival, so we looked at what's being expressed in high-survival patients compared to what's being expressed in low-survival patients," Delfino said.

The team was able to confirm the association of 21 microRNAs with ovarian cancer. They also found 838 target genes and 12 transcription factors associated with ovarian cancer survival and 734 target genes and eight transcription factors associated with ovarian cancer recurrence.

"We were able to find many biomarkers that held the same relationship with survival no matter the cancer treatment, as well as some that were unique in their relationship with survival depending on the treatment the patient had received," Rodriguez-Zas said.

Delfino said that a network-based approach is more predictive of ovarian cancer survival and recurrence than a single-molecule-based perspective.

"We took a step back and looked at everything from a network point of view instead of just individually to see how the components interacted with each other and how the biomarkers were associated with ovarian cancer survival and recurrence," Delfino said.

"This demonstrated that the consideration of networks of microRNAs, transcription factors, and target genes allows us to identify reliable indicators of cancer survival and recurrence and serves as the basis for effective prognostic tools," Rodriguez-Zas said.

Delfino believes this study opens the door to the creation of less invasive diagnostic tests and more specialized treatment options for women with ovarian cancer.

"In the future we'd like to be able to just take a little sample of your DNA and be able to tell you what's going to happen, what we can do to prevent it, and how to cut cancer off before it ever reaches that point," Delfino said. "Everyone is different, and hopefully, we will be able to specify the treatment that will best treat the individual patient."

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The above story is reprinted from materials provided by University of Illinois at Urbana-Champaign.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Kristin R. Delfino, Sandra L. Rodriguez-Zas. Transcription Factor-MicroRNA-Target Gene Networks Associated with Ovarian Cancer Survival and Recurrence. PLoS ONE, 2013; 8 (3): e58608 DOI: 10.1371/journal.pone.0058608

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/t34me9xW0xs/130430092509.htm

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Zinc: The Goldilocks metal for bioabsorbable stents?

Apr. 30, 2013 ? In 2012, more than 3 million people had stents inserted in their coronary arteries. These tiny mesh tubes prop open blood vessels healing from procedures like a balloon angioplasty, which widens arteries blocked by clots or plaque deposits. After about six months, most damaged arteries are healed and stay open on their own. The stent, however, is there for a lifetime.

Most of the time, that's not a problem, says Patrick Bowen, a doctoral student studying materials science and engineering at Michigan Technological University. The arterial wall heals in around the old stent with no ill effect. But the longer a stent is in the body, the greater the risk of late-stage side effects. For example, a permanent stent can cause intermittent inflammation and clotting at the implant site. In a small percentage of cases, the tiny metal segments that make up the stent can break and end up poking the arterial wall.

"When the stent stays in place 15, 20 or 25 years, you can see these side effects," says Bowen. "It's not uncommon to have a stent put in at age 60, and if you live to be 80, that's a long time for something to remain inert in your body."

That's why researchers are trying to develop a bioabsorbable stent, one that would gradually -- and harmlessly -- dissolve after the blood vessel is healed.

Many studies have investigated iron- and magnesium-based stents. However, iron is not promising: it rusts in the artery. Magnesium, on the other hand, dissolves too quickly. "We wondered, 'Isn't there something else?'" Bowen said. "And we thought, 'Why not zinc?'"

So they placed tiny zinc wires in the arteries of rats. The results were amazing. "The corrosion rate was exactly where it needed to be," Bowen said. The wires degraded at a rate just below 0.2 millimeters per year -- the "magic" value for bioabsorbable stents -- for the first three months. After that, the corrosion accelerated, so the implant would not remain in the artery for too long. On top of that, the rats' arteries appeared healthy when the wires were removed, with tissue firmly grasping the implant.

"Plus, zinc reduces atherosclerosis," he added, referring to zinc's well-known ability to fight the development of plaque in the arteries. "How cool is that? A zinc stent might actually have health benefits."

There is one drawback. "A stent made of conventional zinc would not be strong enough to hold open a human artery," he said. "We need to beef it up, double the strength."

"The good news is that there are commercial zinc alloys that are up to three times stronger," Bowen said. "We know we can get there. We just don't want to ruin our corrosion behavior."

The researchers have filed a provisional patent on their discoveries and are now testing new zinc-based stent materials.

An article on their work, "Zinc Exhibits Ideal Physiological Corrosion Behavior for Bioabsorbable Stents," was recently published in the journal Advanced Materials.

Bowen's research is supported by a two-year, $52,000 predoctoral fellowship from the American Heart Association. Initial research was supported by a summer fellowship from the DeVlieg Foundation.

Bowen's advisor is Jaroslaw Drelich, a professor of materials science and engineering, and they work in close collaboration with Jeremy Goldman, an associate professor of biomedical engineering. Undergraduates Jacob Braykovich and Matt Tianen are also working on material development and corrosion testing related to the project.

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The above story is reprinted from materials provided by Michigan Technological University. The original article was written by Marcia Goodrich.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Patrick K. Bowen, Jaroslaw Drelich, Jeremy Goldman. Zinc Exhibits Ideal Physiological Corrosion Behavior for Bioabsorbable Stents. Advanced Materials, 2013; DOI: 10.1002/adma.201300226

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/0zyu7mRzULY/130430194409.htm

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